Scaffold Proposal

If you have ideas for a focused library and wish to participate in CC4CARB to support our objective, please:
  • Complete the scaffold submission form provided in the Word document
  • Upon completion, send the submission form to


Submit electronically

The submission criteria of a proposed scaffold to be considered in CC4CARB are:

  • Description of the scaffold, preferably a structure.
  • Rationale for why the scaffold represents a compelling hypothesis involving the treatment of Gram-negative or antibiotic resistant Gram-positive infections, plus references.
  • Vision for testing scaffold analogs, including key microbes if known. Ability to test compounds is not required.
  • Library design concepts are welcome, but not necessary. Library design will be a collaborative effort between RTI and the external PI.
  • Curriculum Vitae or NIH Biosketch.
  • Innovation, novelty, and concepts addressing Gram-negative antimicrobial discovery and development will be prioritized if accepted.

Proposal and Library Design Samples:

CC4CARB Proposal Sample CC4CARB Library Design Sample (ILPP)

If you have any questions, please email us at or call at the toll-free number (833) 870-0484.

  • Submitted scaffold proposals will be confidential; however, compounds synthesized as a result of an accepted proposal will be made public as part of the CC4CARB collection.
  • A CC4CARB representative may be in contact, if additional information is needed for the proposal.
  • There is no compensation for the preparation of scaffold proposals submitted to CC4CARB; however, funds are available for the preparation of scaffold library plans (ILPPs).
  • No basis for claims against the U.S. Government shall arise because of a response to this project or from the Government's use of such information. The information submitted through the CC4CARB portal will be accessed and reviewed by a Scientific Advisory Board, NIH NIAID, and RTI staff.
  • Information submitted through this portal will be stored on a secure RTI server, and to the extent required under the Freedom of Information Act (FOIA), the submitted information may be subject to public disclosure.